Adaptive Biotechnologies

Step 1: Collect patient bone marrow samples.

Step 2: Send samples to Adaptive Biotechnologies for MRD assessment.

Step 3: Adaptive performs NGS-based MRD analysis.

Step 4: Receive a report with the MRD level, indicating the risk of recurrence.

Step 1: Obtain samples from patients with autoimmune diseases.

Step 2: Perform BCR sequencing to identify antibody repertoires.

Step 3: Analyze the data to identify potential therapeutic antibody candidates.

Step 4: Validate the antibodies in vitro and in vivo.

Step 1: Sequence TCRs from cancer patients.

Step 2: Identify TCRs that recognize tumor-associated antigens.

Step 3: Engineer T cells to express the identified TCRs.

Step 4: Infuse the engineered T cells into patients to target and kill cancer cells.

Step 1: Profile patient immune responses before and during the trial.

Step 2: Identify biomarkers that predict response to the immunotherapy.

Step 3: Stratify patients based on their biomarker profile.

Step 4: Analyze the trial data to assess the efficacy of the drug in different patient subgroups.

Step 1: Collect samples from patients infected with the disease.

Step 2: Perform TCR and BCR sequencing to characterize the immune response.

Step 3: Analyze the data to identify key immune cells and antibodies.

Step 4: Use the information to design more effective vaccines and therapies.