ESMFold

Upload FASTA sequence from soil/ocean samples.

Run ESMFold in batch mode across a GPU cluster.

Analyze output structures for similarity to known enzymes.

Identify novel biocatalysts for industrial applications.

Fold a novel viral protein target using ESMFold.

Verify folding quality via pLDDT scores.

Perform ligand docking simulations on the generated PDB.

Rank potential drug candidates based on binding affinity.

Generate 1000 candidate sequences using a diffusion model.

Filter candidates by passing them through ESMFold.

Select sequences where predicted structure matches the design target.

Move selected sequences to wet-lab synthesis.

Input a sequence with no known homologs.

Utilize ESMFold's language model latent space to infer structure.

Evaluate folding motifs to hypothesize function.

Compare with existing protein databases.

Map mutation landscape of an enzyme.

Fold all variants using ESMFold to detect structural collapses.

Select variants with improved predicted local stability.

Test narrowed-down candidates in a laboratory setting.

Fold individual protein components.

Use ESMFold output to identify surface-exposed hydrophobic patches.

Identify potential binding pockets.

Simulate interactions based on predicted surfaces.

Provide sequences to ESMFold public API.

Obtain structure in under 5 seconds.

Include structure in research papers or preliminary grant data.

Refine later with high-fidelity experimental methods.