Flatiron Health

Define patient cohort criteria (e.g., Stage IV NSCLC with specific mutation).

Query Flatiron's RWD database for historical patient matches.

Extract longitudinal outcomes, including overall survival and time to progression.

Apply statistical matching (Propensity Score Matching) to compare against the trial arm.

Submit findings to regulatory bodies as supplementary evidence.

Upload trial eligibility criteria into the Flatiron platform.

System scans OncoEMR records in real-time across the practice network.

Clinicians receive an alert during the patient visit if a match is found.

The system provides a 'Trial Eligibility Report' summarizing why the patient matches.

The research coordinator initiates the consent process immediately.

Patient undergoes Next-Generation Sequencing (NGS).

Flatiron automatically ingests the genomic report into OncoEMR.

Flatiron Assist flags specific targeted therapies or trials for that mutation.

The clinician reviews the evidence-based recommendation at the point of care.

The targeted therapy is ordered and tracked for outcome analysis.

Flatiron HC automatically aggregates data on 24/7 care access and ER visits.

The platform generates a dashboard showing performance against OCM/EOM benchmarks.

Staff identify high-risk patients needing proactive intervention.

Aggregated reports are submitted directly to CMS via the integrated portal.

The practice receives incentive payments based on documented care quality.

Pharma partner monitors a specific drug cohort in the Flatiron RWD feed.

Adverse event signals are detected in unstructured clinician notes using NLP.

Flatiron data scientists validate the signal against structured lab data.

The manufacturer updates safety protocols or labeling based on real-world findings.

The FDA is notified of the safety profile in a real-world setting.

The health system implements Flatiron Assist across all clinics.

Clinical leads set 'Preferred Pathways' within the tool.

Oncologists receive real-time alerts if their treatment plan deviates from the pathway.

The system captures the reason for deviation (e.g., patient preference).

Leadership reviews monthly reports to drive system-wide standardization.

The practice activates the MyCare patient portal.

Patients receive automated appointment reminders and educational materials.

Lab results are released to the patient securely through the portal.

Patients use the portal to report symptoms (PROs) between visits.

Clinicians adjust treatment plans based on reported symptoms, improving patient satisfaction.